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Image 76 of Progress report (Kentucky Agricultural Experiment Station) n.176

Part of Kentucky Agricultural Experiment Station

-74- INFLUENCE OF VITAMIN A DEFICIENCY ON RENAL FUNCTION IN EWES K. E. Webb, Jr., G. E. Mitchell, Jr., and C. O. Little Vitamin A metabolism has been studied by researchers for several decades. ` Previous Kentucky studies with vitamin A-deficiency in sheep have revealed rather marked changes in plasma and urine composition in the deficient state. An apparent preferential uptake of vitamin A by adrenal glands of vitamin A-deficient sheep has also been observed. The experiments reported here were designed to obtain additional ` information concerning the renal function of sheep during and following vitamin A depletion. Procedure . Fourteen ewes were used in these experiments to study the influence of vitamin A deficiency on the renal function parameters of glomerular filtration rate (GFR) and renal plasma flow (RPF). Creatinine clearance was used to estimate GFR and paminohippuric acid clearance was used to estimate RPF. In addition, the clearances of urea and phosphate were observed. Each ewe was fed 908 gm per day of a carotene- deficient ration composed of ground corncobs, ground milo, and soybean meal. Supplemental vitamin A palmitate (3122 I.U./kg) was added to the ration of seven of the ~ ewes. Results and Discussion After two months liver levels of vitamin A were lower (P < .05) in the group fed the unsupplemented ration (30. 2 vs. 54. 1 mcg/gm) while plasma levels (27. 7 vs. 32. 2 mcg/100 ml) were not significantly different. Renal clearances of creatinine, PAH, ( urea and phosphate were not significantly affected. After 21 months plasma vitamin A _ (4.7 vs. 35.3 mcg/100 ml) was significantly lower (P < . 01) in the group fed the I unsupplemented ration. Both creatinine and PAH clearances were lower (P ( . 05) in this group, indicating decreased glomerular filtration rate and renal plasma flow, respectively. Urea clearance was also decreased (P < . 05) by vitamin A deficiency. Phosphate clearance was elevated but the difference was not significant. Renal clearances were not significantly affected during early vitamin A depletion but were significantly altered after vitamin A stores were fully depleted. BILIARY SECRETION OF METABOLITES OF VITAMIN A AND BETACAROTENE IN SHEEP J. A. Boling, G. E. Mitchell, Jr., C. O. Little, C. L. Fields, and J. L. Call Radioactivity was observed in the feces of steers and lambs injected intravenously with tritiumlabeled vitamin A in earlier experiments at Kentucky. These data suggested that metabolites of vitamin A could have been secreted into the gastrointestinal tract via the bile. The following experiments were conducted to investigate possible biliary secretion of metabolites of vitamin A and beta-carotene in the ruminant.

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